Endocrine Abstracts

Introduction: Cure rate of childhood cancer is a medical success story. However >50% of patients have long term consequences of their cancer treatment. We reviewed data on very long term childhood leukaemia follow-up patients at our institution.Methods: We reviewed electronic patient records for 39 patients (23 female, 16 male; 38-ALL, 1-AML). Multiple chemotherapy regimes were used-low use of anthracyclines/alkylating agents apart from BMT group who...

Objectives: A retrospective review of adult patients with Turner syndrome (TS) attending a joint Turner syndrome clinic.Methods: Sixty-two adult patients with TS clinic were identified. Data was collected from case notes and electronic records.Results: Diagnosis was prenatal/at birth in 20%, 1–10 years in 29%, 11–20 years in 47% and after 21 years in one patient. Common presenting complaints were short stature (51%) and p...

Objective: To audit GH deficiency in the transition service at our institution.Methods: Patients between 19–25 years old were identified from the database of patients having GH replacement. Data were obtained from case notes and electronic records.Results: Twenty-four patients in the transition service were identified to be GH deficient, 13 female and 11 male. 14/24 had CNS or pituitary tumours treated in childhood, 11 having ...

Background: Peri-operative guidelines (POG) published early 2020, were followed by the NHS National Patient Safety Alert (NatPSA) and launch of the NHS Steroid Emergency Card (SEC) in Aug 2020. The NatPSA was sent to all NHS health and care providers. This survey was undertaken to assess the implementation and impact of both.Methods: A pilot survey was undertaken at Endocrine Nurse Update 2022 and amended survey emailed ...

Introduction: The RECOVERY trial2 reported patients with Covid-19 receiving requiring invasive mechanical ventilation or oxygen that the use of dexamethasone (6 mg for 10 days) resulted in lower 28-day mortality. Adrenal insufficiency (AI) from hypothalamic-pituitary-adrenal (HPA) axis suppression3 is a serious, potentially life-threatening side effect of glucocorticoids treatment.Objective: We aimed to investigate the effects of Co...

Case history: A 61-year-old gentleman first presented to A&E following a collapse at work. After missing lunch, he became combative towards his colleagues and was found to be hypoglycaemic with capillary blood glucose of 2.5 mmol/l. Symptoms rapidly improved after oral glucose intake. The patient reported similar episodes in the past, usually occurring before meals and mainly if missing or delaying a meal. The patient did not have any past medical history of note, did not ...

Phaeochromocytomas (PC) are tumours of the adrenal medulla and paragangliomas (PGL) refer to their extra-adrenal counterpart arising from sympathetic or parasympathetic tissue. Mutations in the citric acid cycle enzyme succinate dehydrogenase (SDH) predispose to PC/PGL. Clinical practice guidelines suggest that plasma metanephrine and normetanephrine levels measured in the supine position should be used in the first instance for biochemical diagnosis, and those with positive r...

Introduction: The benefits of growth hormone (rGH) replacement during the transition from childhood to adulthood are well established. In adulthood rGH dose is optimized by titrating to serum IGF-I concentration. The use of non-specific IGF-I reference ranges may result in erroneous assessment of IGF-I concentration and inappropriate rGH dosing.Methods: IGF-I methods and reference ranges across 9 UK centres were reviewed. Immulite IGF-1 results for a 12 ...

Objective: A descriptive study to summarize the experience on diagnosis of NET using various imaging modalities.Methods: Imaging was reviewed for 25 patients between 2002 and 2009 (22 MEN-1, 3 sporadic insulinoma). Of 13/25 had elevated fasting gut hormones. CT, MRI, endoscopic ultrasound (EUS), somatostatin receptor scintigraphy (SRS) and angiography were reviewed. (CT, MRI examined with arterial enhancement).Results: Most frequen...

Background: Pleuro-pulmonary inflammatory fibrotic syndrome is a rare but recognised complication of dopamine agonist (DA) therapy in Parkinson’s disease. Here, we describe a case of asymptomatic pulmonary fibrosis, presumed secondary to DA therapy, in a patient treated with cabergoline for an invasive macroprolactinoma.Case report: A 47-year-old previously fit man was admitted as an emergency with a 3 days history of headache followed by collapse. ...